iMethy is a genome-wide DNA methylation analysis and visualization software based on next generation sequencing.It can be used to align the bisulfite-treated short reads, identify the methylcytosine at CG/CHG/CHH sites, detect the methylation level and annotate the methylcytosine. Meanwhile, more importantly, iMethy can serve as a visualization tool to display bisulfite reads alignment, methylcytosines interrogation and annotation an intuitive graphical interface.

Recent news

1.1.0 release - 31/5/11

• bugs fixed: Save function is not working.

• bugs fixed: Export Image function only exports part of the 1st (top) window.

• bugs fixed: Chromosome pull down box empties when clicked to change.

• bugs fixed: Popup doesn't have enough space for contents.

• bugs fixed: Not enough space for entire descriptions in Global.

• bugs fixed: Unable to choose annotation.

• bugs fixed: Methylation Parameters don't have enough space to show the numbers.

• new feature: mapping pipeline can also run in GUI mode.

Highlights of iMethy:

• Provided a user-friendly interface with memory efficient to display large-scale short reads, obtaining from high-throughput sequencing.

• Powerful visualization property for graphical visualization of genetic variation and associated annotation information.

• Flexible customizable configure supports zooming, font and colors definition schemes.

• Employed the SAM format instead of native format to compact with other software with respect to input/output data format.

• Different visualization section is design as tracks, allowing adding, deleting and rearranging.

• Written in Java programming language and can be performed in an operating system-independent manner for which a Java virtual machine is available.

• Introduced the workspace where users can easy create new project, save the intermediate result.

Intended users:

• Researchers of methylome studies based on high-throughput sequencing.

• For mapping purposes, methylcytosine detections or association studies.

MagicViewer open source codes:

• Welcome to inquiry the open source codes of iMethy.
  If you are interested in the open source codes of iMethy, please contact Jinyu Wu.(iamwujy@yahoo.com.cn)..

A typical screenshot of iMethy: